Category Archive for "Year 2013 Issue 2"

Preparation of innovative hydrogel wound dressings based on poly(acrylic acid)

Katarzyna BIALIK-WĄS, Bożena TYLISZCZAK, Edyta WILK, Krzysztof PIELICHOWSKI ? Department of Chemistry and Technology of Polymers, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Cracow, Poland Abstract: This paper describes new method of preparation of poly(acrylic acid) ? based hydrogel materials under microwave irradiation. The application of poly(ethylene glycol) (PEG), biodegradable and non-toxic polymer, which is widely used in medicine and pharmacy, enabled to control the degree of swelling and degradation of poly(acrylic) matrix. The obtained acrylic...

Synthesis and interaction with albumin of N,N-dimethylaminbenzyl derivative of thiosemicarbazone and its ruthenium(II) complex

Michał ŁOMZIK, Małgorzata BRINDELL ? Inorganic Chemistry Department, Faculty of Chemistry, Jagiellonian University, Cracow, Poland Abstract: Previous studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of...

Nanocarriers in medicine

Justyna SIEMIENIEC ? Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wroclaw, Poland Abstract: Each traditional drug introduced into the body is causing various side effects. This usually results from low specificity, difficulties in reaching its destination, and fast metabolism. To prevent this, in order to improve the biodistribution of the drug, reduce side effects and thus improve the quality of life of patients, intensive research on the use of nanotechnology developments in medicine is...

Rosemary ? a plant rich in biologically active compounds

Krystyna NOWAK, Małgorzata JAWORSKA, Jan OGONOWSKI Institute of Chemistry and Organic Technology, Cracow University of Technology, Cracow, Poland Abstract: The aim of this study is to present the characteristics of biologically active compounds contained in the rosemary (such as rosemary oil, flavonoids, terpenes, phenolic acids) and their use in pharmaceutical, cosmetic and food industries. Please cite as: CHEMIK 2013, 67, 2, 133-138 Introduction Rosemary ( Rosmarinus officinalis L.) is an aromatic, evergreen plant which grows in the wilderness on the coasts...

Comparison of the effectiveness of antibacterial effect of disinfectants on microorganisms isolated from the epidermis

Aleksandra ZIEMBIŃSKA, Marta SZPINDOR - Environmental Biotechnology Department, The Silesian University of Technology, Gliwice, Poland Abstract: Chemical disinfectants are commonly used in households, working places, educational centres etc. However, due to the fast increase of microorganisms? resistance to chemical compounds used in this type of preparations, it is important to choose a suitable and effective disinfectant that prevents bacterial infections in a fast and efficient way. In this study, an attempt was taken to estimate the effectiveness of...

Influence of kind and concentration of emulsifiers from the group of polyethoxylated fatty acids sorbitol esters on the rheological properties of Crodamol PC-based nanoemulsions

Małgorzata JAWORSKA, Elżbieta SIKORA, Jan OGONOWSKI ? Institute of Chemistry and Organic Technology, University of Technology, Cracow, Poland Abstract: The aim of this work was the preparation and rheological characterization of o/w nanoemulsions stabilized by polysorbates, containing Crodamol PC as the oil phase. The formulations were prepared by phase inversion composition method. Measurements of the internal phase droplets size were carried out using Malvern Zetasizer apparatus. The rheological properties of the emulsions systems were studied by using Brookfield...

Comparison of quantitative determination of ?-tocopherol acetate in pharmaceutical preparations by microemulsion electrokinetic chromatography and ultrafast liquid chromatography

Dariusz WIDEŁ, Jerzy OSZCZUDLOWSKI, Zygfryd WITKIEWICZ ? Institute of Chemistry Jan Kochanowski University, Kielce, Poland; Marcin MOCZULSKI ? Comesa Polska Sp. z o.o., Beckman Coulter Biotechnology Division, Warszawa, Poland Abstract: In the present work microemulsion electrokinetic chromatography (MEEKC) was applied for quantitative determination of vitamin E in ?-tocopherol acetate form. Capillary electrophoresis system with diode array detector was used to perform the analysis. Microemulsion consists of: 10 % (w/w) SDS, 6.6 % (w/w) 1-butanol, 0.8 % (w/w) n-octane, 12.5...

Development of Commercially Successful Biosensors for Glucose

Edmond MAGNER ? Materials and Surface Science Institute and Department of Chemical and Environmental Sciences, University of Limerick, Limerick, Ireland Abstract: The development and characterization of electrochemical biosensors is described from the perspective of the development of biosensors for the determination of glucose. The factors that have influenced the large scale commercial development of electrochemical glucose biosensors are discussed. Please cite as: CHEMIK 2013, 67, 2, 105-110 Introduction A biosensor is a device that combines a biological recognition element together with...

Category Archives: Year 2013 Issue 2