Conformational properties of modified amino acid residues
WAŁĘSA R., BUCZEK A., BRODA M.A.
Please cite as: CHEMIK 2014, 68, 4, 329–334
Conformationally constrained amino acids are widely used in the design of peptide analogues with better pharmacokinetic properties. One of the methods of peptide modification is the introduction of a,b-dehydroamino acid residues into peptide chain. The double bond Ca=Cb constrains side chain and enables occurrence of geometrical isomerism Z/E. The other type of...