Significance of UV-Vis spectroscopy in in vitro release studies
GOŚCIAŃSKA J., OLEJNIK A., SOBIESZCZUK E., LATANOWICZ K., NOWAK I.

Please cite as: CHEMIK 2011, 65, 7, 649-654

The in vitro release studies of the active substance with the use of dialysis membrane imitating the skin barrier have been carried out by pharmaceutical concerns for many years. The results contributed to the development of spectroscopic methods which enable estimation of the release rate of active compounds from semisolid dosage forms to a liquid medium as well as characterisation of the kinetics of the process. This article presents the significance of UV-Vis spectroscopy in in vitro release studies of izotretinoin and heparin from various formulations.

Keywords: pharmaceutical bioavailability, UV-Vis spectroscopy, in vitro release studies, semisolids formulations