Evaluation of the efficiency of chiral atropisomeric phosphine ligands in asymmetric processes catalyzed by transition metal salts Part 1: Evaluation of steric effects
DEMCHUK O. M., ŁAST AWI ECKA E.,
K. PIETRUSI EWI CZ M.

Please cite as: CHEMIK 2012, 66, 7, 758-770

Asymmetric synthesis with the use of chiral complexes of transition metals is one of the most economic and environment friendly organic transformations applied in the pharmaceutical industry. However, due to the lack of a universal theory that would bind catalyst structure with synthesis stereoselectivity, selecting an appropriate catalyst for a new reaction is still performed empirically. The aim of this review is to indicate relations between catalyst structure and its efficiency, which may in the future facilitate the selection of an optimum catalytic system.

Keywords: chiral phosphines, atropisomeric ligands, phosphorus ligands, asymmetric catalysis.