Enzymatic slow-binding inhibition
PAWEŁCZAK M. , HUREK J.

Please cite as: CHEMIK 2014, 68, 4, 377–384

Enzyme inhibitors are produced mostly for applications in medicine, crop protection and food industry. Inhibitors slow-binding with enzyme are a group of non-classical inhibitors and such type of inhibition requires more complex analysis of kinetic data. The knowledge of enzyme inhibition mechanisms by inhibitors plays essential role for designing new, more effective compounds of such type. Below, the algorithm is presented that allows to find out what is a mechanism of slow-binding inhibition and the original method for calculating constant Ki for each individual mechanism is shown.

Keywords: enzymatic kinetics, slow-binding inhibition, slowbinding inhibition mechanisms

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